Nature Communications (Nov 2022)

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

  • Joseph G. Kern,
  • Andrew M. Tilston-Lunel,
  • Anthony Federico,
  • Boting Ning,
  • Amy Mueller,
  • Grace B. Peppler,
  • Eleni Stampouloglou,
  • Nan Cheng,
  • Randy L. Johnson,
  • Marc E. Lenburg,
  • Jennifer E. Beane,
  • Stefano Monti,
  • Xaralabos Varelas

DOI
https://doi.org/10.1038/s41467-022-34864-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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LATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinomas.