Nature Communications (Sep 2020)
Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
Abstract
Culture-based diagnostic methods for microorganism detection are time-consuming but still the gold standard for conditions such as sepsis. Here the authors present an amplification and purification-free method to detect microorganisms in bodily fluids with high sensitivity: Single MOLecule Tethering (SMOLT).