Nature Communications (Jan 2022)
Epigenetic aging of the demographically non-aging naked mole-rat
- Csaba Kerepesi,
- Margarita V. Meer,
- Julia Ablaeva,
- Vince G. Amoroso,
- Sang-Goo Lee,
- Bohan Zhang,
- Maxim V. Gerashchenko,
- Alexandre Trapp,
- Sun Hee Yim,
- Ake T. Lu,
- Morgan E. Levine,
- Andrei Seluanov,
- Steve Horvath,
- Thomas J. Park,
- Vera Gorbunova,
- Vadim N. Gladyshev
Affiliations
- Csaba Kerepesi
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Margarita V. Meer
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Julia Ablaeva
- Departments of Biology and Medicine, University of Rochester
- Vince G. Amoroso
- Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago
- Sang-Goo Lee
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Bohan Zhang
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Maxim V. Gerashchenko
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Alexandre Trapp
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Sun Hee Yim
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Ake T. Lu
- Department of Human Genetics, David Geffen School of Medicine, University of California
- Morgan E. Levine
- Department of Pathology, Yale School of Medicine
- Andrei Seluanov
- Departments of Biology and Medicine, University of Rochester
- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California
- Thomas J. Park
- Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago
- Vera Gorbunova
- Departments of Biology and Medicine, University of Rochester
- Vadim N. Gladyshev
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-27959-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.
