Simvastatin is effective in killing the radioresistant breast carcinoma cells

Abstract

Statins, small molecular 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are widely used to lower cholesterol levels in lipid-metabolism disorders. Recent preclinical and clinical studies have shown that statins exert beneficial effects in the management of breast cancer by increasing recurrence free survival. Unfortunately, the underlying mechanisms remain elusive.

Keywords

• breast cancer cells
• cancer stem cells
• radiotherapy
• migration
• simvastatin