Regarding antihypertensive tablets standardization

Abstract

Hypertension is one of the most important problems of medicine related to its prevalence, late diagnosis and inefficient treatment. Antihypertensive treatment is the most effective way to prevent cardiovascular complications and reduce mortality. Most drugs for the treatment of cardiovascular diseases are used in tablet form. So rational dosage form namely tablets has been created for this new drug, namely bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole. The aim of our study was to develop methods for standardization, in particular quantitation of the content of bromide 1-(β-phenylethyl-4-amino-1,2,4-triazole in obtained tablets by spectrophotometric method. Methods and results. We have investigated tablets containing 20 mg of active substance obtained in the laboratory and conducted six experiments. As a result, the obtained tablets containing the active substance meet the requirements of the State Pharmacopoeia of Ukraine. Conclusion. Our method of quantitation of the content of active substance in bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole tablets by spectrophotometric method is convenient and simple in execution, accurate and reproducible and is proposed for Drug master file.

Keywords

• 1 2 4-triazole
• Tablets
• Analysis
• Spectrophotometry