The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection

Shih-Han Ko; Shih-Han Ko; Li-Min Huang; Li-Min Huang; Woan-Yuh Tarn

doi:10.3389/fmicb.2019.02885

Frontiers in Microbiology (Dec 2019)

The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection

Shih-Han Ko,
Shih-Han Ko,
Li-Min Huang,
Li-Min Huang,
Woan-Yuh Tarn

Affiliations

Shih-Han Ko: Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Shih-Han Ko: Department of Pediatrics, National Taiwan University Children’s Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Li-Min Huang: Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Li-Min Huang: Department of Pediatrics, National Taiwan University Children’s Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Woan-Yuh Tarn: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

DOI: https://doi.org/10.3389/fmicb.2019.02885
Journal volume & issue: Vol. 10

Abstract

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A variety of pathogens take advantage of cellular heat shock proteins (HSPs) to complete their life cycle and exert pathogenic effects. MRJ (DNAJB6), a member of the heat shock protein 40 family, acts as a molecular chaperone for a wide range of cellular processes. MRJ mutations are linked to human diseases, such as muscular dystrophy and neurodegenerative diseases. There are two MRJ isoforms generated by alternative use of terminal exons, which differ in their C-terminus. This mini-review summarizes how these two MRJ isoforms participate differentially in viral production and virulence, and the possibility for MRJ as a therapeutic target.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

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Abstract

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