Caspase-3 and Caspase-8 in Patients with Nodular Goiter and Autoimmune Thyroiditis

Abstract

The article presents results of the comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and nodular goiter with autoimmune thyroiditis (NGAIT). Studying peroxidation processes in the tissue of the thyroid gland abnormal tissue was detected to be characterized by increase in of protein oxidative modification (POM) indices at the same time, the antioxidant enzymes activity (AEA) was significantly reduced and was more likely in patients with NGAIT. Significant increase in activity of both caspase 3 and 8 was shown in patients with NGAIT compared to macroscopically unchanged tissue and thyroid adenoma. Possible mechanisms of the detected disorders were discussed.

Keywords

• nodular goiter with autoimmune thyroiditis
• thyroid adenoma
• apoptosis
• peroxidation
• caspase 3
• caspase 8