PLoS ONE (Jan 2014)

The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.

  • Xun Niu,
  • Xiong Chen,
  • Ying Xiao,
  • Jiaqi Dong,
  • Rui Zhang,
  • Meixia Lu,
  • Weijia Kong

DOI
https://doi.org/10.1371/journal.pone.0095794
Journal volume & issue
Vol. 9, no. 4
p. e95794

Abstract

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BackgroundStudies have reported inconsistent findings regarding the relationship between obstructive sleep apnea (OSA) and homocysteine (HCY) level. This study aimed to assess the difference in plasma HCY level between OSA patients and controls by conducting a meta-analysis of published studies.MethodsDatabase of PubMed, SCI, and China National Knowledge Internet (CNKI) were comprehensively searched. Eligible studies regarding plasma HCY level in OSA patients were identified by two independent reviewers. RevMan (version 5.2) and STATA (version 12.0) were employed for data synthesis.ResultsA total of 10 studies involving 432 subjects were included. Meta-analysis showed that plasma HCY levels in OSA group were 3.11 µmol/l higher than that in control group (95% confidence interval: 2.08 to 4.15, PConclusionsIn this meta-analysis, plasma HCY levels were found to be higher in OSA patients compared to control subjects.