BMC Cancer (Feb 2019)
The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases
- Rainer J. Klement,
- N. Abbasi-Senger,
- S. Adebahr,
- H. Alheid,
- M. Allgaeuer,
- G. Becker,
- O. Blanck,
- J. Boda-Heggemann,
- T. Brunner,
- M. Duma,
- M. J. Eble,
- I. Ernst,
- S. Gerum,
- D. Habermehl,
- P. Hass,
- C. Henkenberens,
- G. Hildebrandt,
- D. Imhoff,
- H. Kahl,
- N. D. Klass,
- R. Krempien,
- V. Lewitzki,
- F. Lohaus,
- C. Ostheimer,
- A. Papachristofilou,
- C. Petersen,
- J. Rieber,
- T. Schneider,
- E. Schrade,
- R. Semrau,
- S. Wachter,
- A. Wittig,
- M. Guckenberger,
- N. Andratschke
Affiliations
- Rainer J. Klement
- Department of Radiation Oncology, Leopoldina Hospital Schweinfurt
- N. Abbasi-Senger
- Department of Radiation Oncology, University Hospital Jena
- S. Adebahr
- Department of Radiation Oncology, University Hospital Freiburg
- H. Alheid
- Strahlentherapie Bautzen
- M. Allgaeuer
- Department of Radiation Oncology, Hospital Barmherzige Brueder
- G. Becker
- RadioChirurgicum CyberKnife Suedwest
- O. Blanck
- Department of Radiation Oncology Universitaetsklinikum Schleswig-Holstein
- J. Boda-Heggemann
- Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg
- T. Brunner
- Department of Radiation Oncology, University Hospital Freiburg
- M. Duma
- Department of Radiation Oncology, Klinikum rechts der Isar- Technische Universitaet Muenchen
- M. J. Eble
- Department of Radiation Oncology, University Hospital Aachen
- I. Ernst
- Department of Radiation Oncology, University Hospital Muenster
- S. Gerum
- Department of Radiation Oncology, Ludwig Maximilians University Munich
- D. Habermehl
- Department of Radiation Oncology, Klinikum rechts der Isar- Technische Universitaet Muenchen
- P. Hass
- Department of Radiation Oncology, University Hospital Magdeburg
- C. Henkenberens
- Department of Radiotherapy and Special Oncology, Medical School Hannover
- G. Hildebrandt
- Department of Radiation Oncology, University of Rostock
- D. Imhoff
- Department of Radiation Oncology, University Hospital Frankfurt
- H. Kahl
- Department of Radiation Oncology, Hospital Augsburg
- N. D. Klass
- Department of Radiation Oncology, University Hospital Bern
- R. Krempien
- Department of Radiation Oncology, Helios Klinikum Berlin Buch
- V. Lewitzki
- Department of Radiation Oncology, University Hospital Wuerzburg
- F. Lohaus
- Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden
- C. Ostheimer
- Department of Radiation Oncology, University Hospital Halle
- A. Papachristofilou
- Department of Radiation Oncology, University Hospital Hamburg
- C. Petersen
- Department of Radiation Oncology, University Hospital Basel
- J. Rieber
- Department of Radiation Oncology, University Hospital Heidelberg
- T. Schneider
- Strahlenzentrum Hamburg
- E. Schrade
- Department of Radiation Oncology, Hospital Heidenheim
- R. Semrau
- Department of Radiation Oncology, University Hospital of Cologne
- S. Wachter
- Department of Radiation Oncology, Klinikum Passau
- A. Wittig
- Department of Radiation Oncology, University Hospital Jena
- M. Guckenberger
- Department of Radiation Oncology, University Hospital Zurich, University of Zurich
- N. Andratschke
- Department of Radiation Oncology, University Hospital Zurich, University of Zurich
- DOI
- https://doi.org/10.1186/s12885-019-5362-5
- Journal volume & issue
-
Vol. 19,
no. 1
pp. 1 – 12
Abstract
Abstract Background The aim of this analysis was to model the effect of local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer. Methods The analysis is based on pooled data from two retrospective SBRT databases for pulmonary and hepatic metastases from 27 centers from Germany and Switzerland. Only patients with metastases from colorectal cancer were considered to avoid histology as a confounding factor. An illness-death model was employed to model the relationship between LC and OS. Results Three hundred eighty-eight patients with 500 metastatic lesions (lung n = 209, liver n = 291) were included and analyzed. Median follow-up time for local recurrence assessment was 12.1 months. Ninety-nine patients with 112 lesions experienced local failure. Seventy-one of these patients died after local failure. Median survival time was 27.9 months in all patients and 25.4 months versus 30.6 months in patients with and without local failure after SBRT. The baseline risk of death after local failure exceeds the baseline risk of death without local failure at 10 months indicating better survival with LC. Conclusion In CRC patients with lung or liver metastases, our findings suggest improved long-term OS by achieving metastatic disease control using SBRT in patients with a projected OS estimate of > 12 months.
Keywords
- Colorectal cancer
- Illness-death model
- Liver metastases
- Lung metastases
- Tumor control probability
- Stereotactic body radiation therapy
