Nature Communications (Feb 2019)
Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming
- Naoto Muraoka,
- Kaori Nara,
- Fumiya Tamura,
- Hidenori Kojima,
- Hiroyuki Yamakawa,
- Taketaro Sadahiro,
- Kazutaka Miyamoto,
- Mari Isomi,
- Sho Haginiwa,
- Hidenori Tani,
- Shota Kurotsu,
- Rina Osakabe,
- Satoru Torii,
- Shigeomi Shimizu,
- Hideyuki Okano,
- Yukihiko Sugimoto,
- Keiichi Fukuda,
- Masaki Ieda
Affiliations
- Naoto Muraoka
- Department of Cardiology, Keio University School of Medicine
- Kaori Nara
- Department of Cardiology, Keio University School of Medicine
- Fumiya Tamura
- Department of Cardiology, Keio University School of Medicine
- Hidenori Kojima
- Department of Cardiology, Keio University School of Medicine
- Hiroyuki Yamakawa
- Department of Cardiology, Keio University School of Medicine
- Taketaro Sadahiro
- Department of Cardiology, Faculty of Medicine, University of Tsukuba
- Kazutaka Miyamoto
- Department of Cardiology, Keio University School of Medicine
- Mari Isomi
- Department of Cardiology, Faculty of Medicine, University of Tsukuba
- Sho Haginiwa
- Department of Cardiology, Keio University School of Medicine
- Hidenori Tani
- Department of Cardiology, Keio University School of Medicine
- Shota Kurotsu
- Department of Cardiology, Keio University School of Medicine
- Rina Osakabe
- Department of Cardiology, Keio University School of Medicine
- Satoru Torii
- Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)
- Shigeomi Shimizu
- Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)
- Hideyuki Okano
- Department of Physiology, Keio University School of Medicine
- Yukihiko Sugimoto
- Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University
- Keiichi Fukuda
- Department of Cardiology, Keio University School of Medicine
- Masaki Ieda
- Department of Cardiology, Faculty of Medicine, University of Tsukuba
- DOI
- https://doi.org/10.1038/s41467-019-08626-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Fibroblasts can be directly reprogrammed to cardiomyocytes, but reprogramming is less efficient for adult compared to embryonic fibroblasts. Here, the authors find that inhibition of inflammation and Cox-2-prostaglandin-cAMP-IL-1β signaling enhances reprogramming efficiency of adult, but not embryonic fibroblasts.
