Nature Communications (Oct 2021)

The GPR171 pathway suppresses T cell activation and limits antitumor immunity

  • Yuki Fujiwara,
  • Robert J. Torphy,
  • Yi Sun,
  • Emily N. Miller,
  • Felix Ho,
  • Nicholas Borcherding,
  • Tuoqi Wu,
  • Raul M. Torres,
  • Weizhou Zhang,
  • Richard D. Schulick,
  • Yuwen Zhu

DOI
https://doi.org/10.1038/s41467-021-26135-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Proliferative and effector functions of T cells are determined by T cell receptor signalling and modulated by activator and inhibitory co-receptors. Authors report here that the G-protein-coupled receptor GPR171 functions as a co-inhibitor of T cell signalling and might serve as a target for cancer immunotherapy.