Malondialdehyde Levels in Preeclampsia before and after Delivery

Abstract

Objective: Determine differences plasma levels MDA in preeclampsia before and 2 hours after delivery. Methods: This was an analytic cross-sectional study. Subject consists of 23 pregnancies with preeclampsia, where 23 blood samples taken before delivery and 23 were taken 2 hours after delivery. This study was conducted from August 2016 until December 2016 at Department of Obstetrics and Gynecology Faculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D. Kandou Hospital Manado and satellite hospital. Samples were taken from plasma and analysed using HPLC method at Prodia clinical laboratory. Results: In patients with severe preeclampsia before delivery we found average value (1.4796  0.40819 nmol/ml), minimum value (1.03 nmol/ml) and maximal value (2.77 nmol/ml) and 2 hours after delivery with average value (1.2470  0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximum value (2.47 nmol/ml). by using Wilcoxon test, we found there were significant differences in plasma levels of MDA (p = 0.000). Conclusion: This significant difference suggests that decreased plasma levels of MDA 2 hours after delivery and gives the sense that there is a relationship between oxidative stress of cells with severe preeclampsia before and shortly after delivery, that MDA is an indicator of oxidative stress. Keywords: malondialdehyde, oxidative stress, peroxidation lipid, preeclampsia