Age-specific differences in the dynamics of protective immunity to influenza

Sylvia Ranjeva; Rahul Subramanian; Vicky J. Fang; Gabriel M. Leung; Dennis K. M. Ip; Ranawaka A. P. M. Perera; J. S. Malik Peiris; Benjamin J. Cowling; Sarah Cobey

doi:10.1038/s41467-019-09652-6

Nature Communications (Apr 2019)

Age-specific differences in the dynamics of protective immunity to influenza

Sylvia Ranjeva,
Rahul Subramanian,
Vicky J. Fang,
Gabriel M. Leung,
Dennis K. M. Ip,
Ranawaka A. P. M. Perera,
J. S. Malik Peiris,
Benjamin J. Cowling,
Sarah Cobey

Affiliations

Sylvia Ranjeva: Department of Ecology and Evolution, University of Chicago
Rahul Subramanian: Department of Ecology and Evolution, University of Chicago
Vicky J. Fang: WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson Building
Gabriel M. Leung: WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson Building
Dennis K. M. Ip: WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson Building
Ranawaka A. P. M. Perera: WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson Building
J. S. Malik Peiris: WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson Building
Benjamin J. Cowling: WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson Building
Sarah Cobey: Department of Ecology and Evolution, University of Chicago

DOI: https://doi.org/10.1038/s41467-019-09652-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Protective immunity after influenza virus infection is poorly understood. Here, the authors quantify the dynamics of immunity against influenza A virus infections by fitting individual-level mechanistic models to longitudinal serology, and find that the form and dynamics of protection differ between children and adults.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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