Терапевтический архив (Mar 2023)

Effectiveness of empirical <i>Helicobacter pylori</i> eradication therapy with furazolidone in Russia: results from the European Registry on <i>Helicobacter pylori</i> Management (Hp-EuReg)

  • Dmitry S. Bordin,
  • Irina N. Voynovan,
  • Aiman S. Sarsenbaeva,
  • Oleg V. Zaytsev,
  • Rustam A. Abdulkhakov,
  • Natalia V. Bakulina,
  • Igor G. Bakulin,
  • Marina F. Osipenko,
  • Maria A. Livzan,
  • Sergei A. Alekseenko,
  • Larisa V. Tarasova,
  • Galina N. Tarasova,
  • Pavel O. Bogomolov,
  • Igor V. Maev,
  • Dmitry N. Andreev,
  • Sayar R. Abdulkhakov,
  • Boris D. Starostin,
  • Natalia V. Bakanova,
  • Alla G. Kononova,
  • Sergei V. Kolbasnikov,
  • Elena L. Bueverova,
  • Leticia Moreira,
  • Francis Megraud,
  • Colm O'Morain,
  • Olga Perez Nyssen,
  • Javier Perez Gisbert

DOI
https://doi.org/10.26442/00403660.2023.02.202107
Journal volume & issue
Vol. 95, no. 2
pp. 120 – 129

Abstract

Read online

Background. First-line therapy does not always provide a high level of Helicobacter pylori eradication due to the increase of H. pylori resistance to antibiotics; therefore, it remains necessary to identify the most effective rescue treatments. The purpose of this study was to evaluate the efficacy and safety of empirical H. pylori furazolidone-containing regimens. Materials and methods. Adult H. pylori infected patients empirically treated with furazolidone-containing eradication regimens were registered in an international, prospective, multicenter non-intervention European registry on H. pylori management (Hp-EuReg). Data were collected at AEG-REDCap e-CRF from 2013 to 2021 and the quality was reviewed. Modified intention-to-treat (mITT) effectiveness analyses were performed. Results. Overall 106 patients received empirical furazolidone-containing therapy in Russia. Furazolidone was prescribed in a sequential scheme along with amoxicillin, clarithromycin and a proton pump inhibitor in 68 (64%) cases, triple regimens were prescribed in 28 (26%) patients and quadruple regimens in 10 (9.4%). Treatment duration of 7 days was assigned to 2 (1.9%) patients, 10-day eradication therapy in case of 80 (75%) and 14 days in 24 (23%) patients. Furazolidone was mainly used in first- (79%) and second-line (21%) regimens. The methods used to diagnose H. pylori infection were: histology (81%), stool antigen test (64%), 13C-urea breath test (6.6%), and rapid urease test (1.9%). The mITT effectiveness of sequential therapy was 100%; 93% with the triple therapy and 75.5% with quadruple therapy. Compliance was reported in 98% of cases. Adverse events were revealed in 5.7% of patients, mostly nausea (3.8%). No serious adverse events were reported. Conclusion. Furazolidone containing eradication regimens appear to be an effective and safe empirical therapy in Russia.

Keywords