Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

• Carla Casu,
• Mariam Aghajan,
• Paraskevi Rea Oikonomidou,
• Shuling Guo,
• Brett P. Monia,
• Stefano Rivella

Affiliations

Carla Casu

Children’s Hospital of Philadelphia (CHOP), Department of Pediatrics, Division of Hematology, PA

Mariam Aghajan

Isis Pharmaceuticals, Inc. Carlsbad, CA, USA

Paraskevi Rea Oikonomidou

Children’s Hospital of Philadelphia (CHOP), Department of Pediatrics, Division of Hematology, PA

Shuling Guo

Isis Pharmaceuticals, Inc. Carlsbad, CA, USA

Brett P. Monia

Isis Pharmaceuticals, Inc. Carlsbad, CA, USA

Stefano Rivella

Children’s Hospital of Philadelphia (CHOP), Department of Pediatrics, Division of Hematology, PA