AGE ASPECT OF THE INFLUENCE OF HYPERTYROXYNEMIA ON BEHAVIORAL ACTIVITY AND ON THE STATE OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE STRUCTURES OF THE HEADS

Abstract

Today thyroid dysfunction is a current problem among the whole set of endocrine diseases. In this paper, a review of the literature on the influence of hyperthyroxinemia on behavioral activity and the state of the prooxidant and antioxidant systems in the brain structures of experimental animals, taking into account the age aspect. The role of excess T4 in the ontogenesis of rats is indicated, which causes considerable controversy in the scientific community, mainly due to the lack of thorough research on the mechanism of influence on behavioral activity and the state of prooxidant and antioxidant systems. The actual characteristics of the connection between hyperthyroxinemia and oxidative stress in the structures of the brain are presented. The functional features of the enzymatic component and participation in the implementation of a complex neurochemical system under conditions of deficiency of components of the cellular composition of the CNS are emphasized. Particular attention was paid to the analysis of data found in the open field test, also compared, taking into account the age aspect, the current results of behavioral reactions in juvenile, young and old rats related to changes in the number and duration of stays in the sleeves; the role of CNS mediators (serotonin, GABA, glutamate) is generalized in this. Current literature does not provide a definitive answer on the degree of susceptibility to anxiogenic effects and changes in resistance to anxiety (resulting from the action of thyroid hormones on rats during behavioral testing), and data on thyroid dysfunction of the combined effect of antioxidant balance sufficient and remain unfinished issues of their coverage for society as a whole.

Keywords

• hyperthyroxinemia
• behavioral activity
• antioxidant system
• rats of different ages
• ontogenesis.