Prevalence of hemoglobinopathies in pregnant women, Sancti Spíritus province

Abstract

Introduction: hemoglobinopathies are a group of genetic diseases, caused by disorders in the structure of hemoglobin chains. The Cuban National Health System's priority is the early diagnosis of these diseases. Objectives: to characterize the behavior of hemoglobinopathies in pregnant women in Sancti Spíritus province in the period from 2011 to 2018. Methods: an observational, descriptive, longitudinal and retrospective study was conducted using the databases of the Provincial Center of Medical Genetics of Sancti Spíritus. The universe consisted of 28 461 pregnant women who were studied and the sample was 756 pregnant women who presented some kind of hemoglobinopathies. Results: out of the total number of pregnant women studied, 2,56 % were carriers of hemoglobinopathies, 90,60 % of the couples were studied and a total of 32 couples on risk were diagnosed and genetically counseled. The most common variants of hemoglobinopathies were AS (79,89 %) and AC (14,42 %). The municipalities with the highest number of hemoglobinopathies carriers were Sancti Spíritus (30,03 %) and Trinidad (28,70 %). Conclusions: the prevalence of hemoglobinopathies in pregnant women in Sancti Spíritus province was described. A low prevalence of hemoglobinopathies is shown in pregnant women from Sancti Spíritus province.

Keywords

• hemoglobinopatías
• electroforesis de las proteínas sanguíneas
• anemia de células falciformes.