Nature Communications (Feb 2021)
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome
- Sabine A. Hartlieb,
- Lina Sieverling,
- Michal Nadler-Holly,
- Matthias Ziehm,
- Umut H. Toprak,
- Carl Herrmann,
- Naveed Ishaque,
- Konstantin Okonechnikov,
- Moritz Gartlgruber,
- Young-Gyu Park,
- Elisa Maria Wecht,
- Larissa Savelyeva,
- Kai-Oliver Henrich,
- Carolina Rosswog,
- Matthias Fischer,
- Barbara Hero,
- David T. W. Jones,
- Elke Pfaff,
- Olaf Witt,
- Stefan M. Pfister,
- Richard Volckmann,
- Jan Koster,
- Katharina Kiesel,
- Karsten Rippe,
- Sabine Taschner-Mandl,
- Peter Ambros,
- Benedikt Brors,
- Matthias Selbach,
- Lars Feuerbach,
- Frank Westermann
Affiliations
- Sabine A. Hartlieb
- Hopp Children’s Cancer Center (KiTZ)
- Lina Sieverling
- Faculty of Biosciences, Heidelberg University
- Michal Nadler-Holly
- Proteome Dynamics, Max Delbrück Center for Molecular Medicine
- Matthias Ziehm
- Proteome Dynamics, Max Delbrück Center for Molecular Medicine
- Umut H. Toprak
- Hopp Children’s Cancer Center (KiTZ)
- Carl Herrmann
- Health Data Science Unit, Medical Faculty Heidelberg and BioQuant
- Naveed Ishaque
- Digital Health Centre, Berlin Institute of Health (BIH)
- Konstantin Okonechnikov
- Hopp Children’s Cancer Center (KiTZ)
- Moritz Gartlgruber
- Hopp Children’s Cancer Center (KiTZ)
- Young-Gyu Park
- Hopp Children’s Cancer Center (KiTZ)
- Elisa Maria Wecht
- Hopp Children’s Cancer Center (KiTZ)
- Larissa Savelyeva
- Hopp Children’s Cancer Center (KiTZ)
- Kai-Oliver Henrich
- Hopp Children’s Cancer Center (KiTZ)
- Carolina Rosswog
- Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty
- Matthias Fischer
- Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty
- Barbara Hero
- Department of Pediatric Oncology and Hematology, University of Cologne
- David T. W. Jones
- Hopp Children’s Cancer Center (KiTZ)
- Elke Pfaff
- Hopp Children’s Cancer Center (KiTZ)
- Olaf Witt
- Hopp Children’s Cancer Center (KiTZ)
- Stefan M. Pfister
- Hopp Children’s Cancer Center (KiTZ)
- Richard Volckmann
- Department of Oncogenomics Amsterdam University Medical Centers (AUMC)
- Jan Koster
- Department of Oncogenomics Amsterdam University Medical Centers (AUMC)
- Katharina Kiesel
- Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant
- Karsten Rippe
- Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant
- Sabine Taschner-Mandl
- CCRI, St Anna Children’s Cancer Research Institute
- Peter Ambros
- CCRI, St Anna Children’s Cancer Research Institute
- Benedikt Brors
- Applied Bioinformatics, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)
- Matthias Selbach
- Proteome Dynamics, Max Delbrück Center for Molecular Medicine
- Lars Feuerbach
- Applied Bioinformatics, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)
- Frank Westermann
- Hopp Children’s Cancer Center (KiTZ)
- DOI
- https://doi.org/10.1038/s41467-021-21247-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Alternative lengthening of telomeres (ALT) is associated with a poor outcome in neuroblastoma. Here, the authors find that ALT is associated with mutated ATRX and/or reduced protein abundance, frequent telomeric repeat loci and heterochromatic telomeric chromatin.
