Paraneoplastic syndrome in malignant lymphoma: A case report
Dian Yu,
Xinyi Tang,
Haoyue Xue,
Yongfeng Ao,
Yongpeng Xie,
Xiaomin Li
Affiliations
Dian Yu
Lianyungang Clinical College of Nanjing Medical University, China; Department of Emergency and Critical Care Medicine, The First People's Hospital of Lianyungang, China; Clinical College of Guizhou Medical University, China
Xinyi Tang
Lianyungang Clinical College of Nanjing Medical University, China; Department of Emergency and Critical Care Medicine, The First People's Hospital of Lianyungang, China
Haoyue Xue
Department of Emergency and Critical Care Medicine, The First People's Hospital of Lianyungang, China; Lianyungang Clinical College of Xuzhou Medical University, China
Yongfeng Ao
Clinical College of Guizhou Medical University, China
Yongpeng Xie
Lianyungang Clinical College of Nanjing Medical University, China; Department of Emergency and Critical Care Medicine, The First People's Hospital of Lianyungang, China; Lianyungang Clinical College of Xuzhou Medical University, China; Corresponding author. Lianyungang Clinical College of Nanjing Medical University, China.
Xiaomin Li
Lianyungang Clinical College of Nanjing Medical University, China; Department of Emergency and Critical Care Medicine, The First People's Hospital of Lianyungang, China; Lianyungang Clinical College of Xuzhou Medical University, China; Corresponding author. Department of Emergency Critical Care, Lianyungang First People's Hospital, Lianyungang City, Jiangsu Province, 222000, China.
Hypercalcaemia associated with malignancy is a complication of advanced tumors. Lactic acidosis is also an extremely rare paraneoplastic syndrome of malignancy, and the presence of both usually indicates an extremely poor prognosis for the tumour. Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma and is also a common aggressive lymphoma. It is extremely rare for patients with diffuse large B-cell lymphoma to develop both hypercalcaemia and severe lactic acidosis. In this article, we report a case of CD5 positive diffuse large B-cell lymphoma with hypercalcaemic crisis and persistent lactic acidosis, in which calcium was rapidly reduced to normal after rehydration, diuresis, calcitonin and zoledronate, and continuous renal replacement therapy (CRRT). After correction of acidosis with sodium bicarbonate, diuresis, vitamin B1 and CRRT, the patient's lactate remained at a high level. The aim of this article is to analyse the experience of the combination of hypercalcaemia and intractable lactic acidosis, which should be considered as a serious electrolyte disorder possibly associated with abnormal metabolism of malignant tumors, and to identify and treat the primary lesion as early as possible.
