Formulation and standardization of Yashtimadhu Kalpa (Granule): A novel Medhya Rasayana

Abstract

Background: Ayurveda, the Indian system of medicine, is the first recorded medical science widely practiced in India since ancient times. As per Ayurveda, the drugs that help to improve and preserve intellect, i.e., Medha are termed as Medhya. Yashtimadhu (Glycyrrhiza glabra Linn.) is one among the four Medhya Rasayana (memory promotive drugs) mentioned by Acharya Charaka. In the present study, an effort was made to prepare palatable and easily administrable formulation of Yashtimadhu Churna as Yashtimadhu Kalpa (granules) and to standardize the same. Materials and Methods: Raw material was procured and preliminary physiochemical analysis was performed. Yashtimadhu coarse powder was taken in the vessel and 16 parts of water were added to it. Yashtimadhu Kwatha was prepared by reducing it to 1/8th and filtered through a cotton cloth. Coarsely powdered Sita twice of Yashtimadhu Kwatha was added in it and heated on mild fire up to100°C. Heating was continued till it attained sticky consistency before the granulation stage. The mixture was taken out of the vessel and dried in a hot air oven. Then, it was sieved in the multi mill to obtain granules. To validate the safety of Yashtimadhu Kalpa (granules) for the internal use, the final product the Yashtimadhu Kalpa was standardized and microbial analysis was done. Results: Granulation was done with the help of a granulation machine, which took 3 h 50 min for granulation; thus, a total of 5 h 50 min were required to obtain a yield of 8.5 kg. The granules of Yashtimadhu Kalpa are solid crystalline free-flowing, cream color and characteristics smell, granules, characteristic sweet, soluble in milk, palatable, and tasty. Conclusion: The novel preparation Yashtimadhu Kalpa (granules) is palatable, tasty, soluble, well preserved, and free from microbes.

Keywords

• granules
• kalpa
• medhya
• standardization
• yashtimadhu