Galectin-9 binds IgM-BCR to regulate B cell signaling

Anh Cao; Nouf Alluqmani; Fatima Hifza Mohammed Buhari; Laabiah Wasim; Logan K. Smith; Andrew T. Quaile; Michael Shannon; Zaki Hakim; Hossai Furmli; Dylan M. Owen; Alexei Savchenko; Bebhinn Treanor

doi:10.1038/s41467-018-05771-8

Nature Communications (Aug 2018)

Galectin-9 binds IgM-BCR to regulate B cell signaling

Anh Cao,
Nouf Alluqmani,
Fatima Hifza Mohammed Buhari,
Laabiah Wasim,
Logan K. Smith,
Andrew T. Quaile,
Michael Shannon,
Zaki Hakim,
Hossai Furmli,
Dylan M. Owen,
Alexei Savchenko,
Bebhinn Treanor

Affiliations

Anh Cao: Department of Immunology, University of Toronto
Nouf Alluqmani: Department of Cell and Systems Biology, University of Toronto
Fatima Hifza Mohammed Buhari: Department of Biological Sciences, University of Toronto Scarborough
Laabiah Wasim: Department of Immunology, University of Toronto
Logan K. Smith: Department of Immunology, University of Toronto
Andrew T. Quaile: Department of Chemical Engineering and Applied Chemistry, University of Toronto
Michael Shannon: Department of Physics and Randall Division of Cell and Molecular Biophysics, New Hunt’s House, King’s College London Guy’s Campus
Zaki Hakim: Department of Cell and Systems Biology, University of Toronto
Hossai Furmli: Department of Biological Sciences, University of Toronto Scarborough
Dylan M. Owen: Department of Physics and Randall Division of Cell and Molecular Biophysics, New Hunt’s House, King’s College London Guy’s Campus
Alexei Savchenko: Department of Chemical Engineering and Applied Chemistry, University of Toronto
Bebhinn Treanor: Department of Immunology, University of Toronto

DOI: https://doi.org/10.1038/s41467-018-05771-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association between IgM and CD22.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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