mBio
(Oct 2021)
Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
Alex W. Wessel,
Michael P. Doyle,
Taylor B. Engdahl,
Jessica Rodriguez,
James E. Crowe,
Michael S. Diamond
Affiliations
Alex W. Wessel
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
Michael P. Doyle
Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Taylor B. Engdahl
ORCiD Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Jessica Rodriguez
Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
James E. Crowe
ORCiD Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Michael S. Diamond
ORCiD Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
DOI
https://doi.org/10.1128/mBio.02440-21
Journal volume & issue
Vol. 12,
no. 5
Abstract
Read online
Therapeutic antibodies against flaviviruses often promote neutralization by targeting the envelope protein of the virion. However, this approach is hindered by a possible concern for antibody-dependent enhancement of infection and paradoxical worsening of disease.
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