Nature Communications (Jun 2021)
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis
- Diana Monsivais,
- Takashi Nagashima,
- Renata Prunskaite-Hyyryläinen,
- Kaori Nozawa,
- Keisuke Shimada,
- Suni Tang,
- Clark Hamor,
- Julio E. Agno,
- Fengju Chen,
- Ramya P. Masand,
- Steven L. Young,
- Chad J. Creighton,
- Francesco J. DeMayo,
- Masahito Ikawa,
- Se-Jin Lee,
- Martin M. Matzuk
Affiliations
- Diana Monsivais
- Department of Pathology & Immunology, Baylor College of Medicine
- Takashi Nagashima
- Department of Pathology & Immunology, Baylor College of Medicine
- Renata Prunskaite-Hyyryläinen
- Faculty of Biochemistry and Medicine, University of Oulu
- Kaori Nozawa
- Department of Pathology & Immunology, Baylor College of Medicine
- Keisuke Shimada
- Research Institute for Microbial Disease, Osaka University
- Suni Tang
- Department of Pathology & Immunology, Baylor College of Medicine
- Clark Hamor
- Department of Pathology & Immunology, Baylor College of Medicine
- Julio E. Agno
- Department of Pathology & Immunology, Baylor College of Medicine
- Fengju Chen
- Department of Medicine, Baylor College of Medicine
- Ramya P. Masand
- Department of Pathology & Immunology, Baylor College of Medicine
- Steven L. Young
- Department of Obstetrics and Gynecology, University of North Carolina
- Chad J. Creighton
- Department of Medicine, Baylor College of Medicine
- Francesco J. DeMayo
- National Institute of Environmental Health Sciences
- Masahito Ikawa
- Research Institute for Microbial Disease, Osaka University
- Se-Jin Lee
- Jackson Laboratory for Genomic Medicine
- Martin M. Matzuk
- Department of Pathology & Immunology, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23571-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Building on the known role of BMP signalling in implantation, the authors define the role of uterine ACVR2A and ALK3 (via SMAD1/5) in vivo in regulating murine endometrial receptivity and embryo implantation.
