Nature Communications (Dec 2018)
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne
- Christos Petridis,
- Alexander A. Navarini,
- Nick Dand,
- Jake Saklatvala,
- David Baudry,
- Michael Duckworth,
- Michael H. Allen,
- Charles J. Curtis,
- Sang Hyuck Lee,
- A. David Burden,
- Alison Layton,
- Veronique Bataille,
- Andrew E. Pink,
- The Acne Genetic Study Group,
- Isabelle Carlavan,
- Johannes J. Voegel,
- Timothy D. Spector,
- Richard C. Trembath,
- John A. McGrath,
- Catherine H. Smith,
- Jonathan N. Barker,
- Michael A. Simpson
Affiliations
- Christos Petridis
- Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King’s College London
- Alexander A. Navarini
- Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King’s College London
- Nick Dand
- Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King’s College London
- Jake Saklatvala
- Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King’s College London
- David Baudry
- St John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London
- Michael Duckworth
- St John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London
- Michael H. Allen
- St John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London
- Charles J. Curtis
- NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London
- Sang Hyuck Lee
- NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London
- A. David Burden
- Institute of Infection, Immunity and Inflammation, University of Glasgow
- Alison Layton
- Department of Dermatology, Harrogate and District Foundation Trust
- Veronique Bataille
- Twin Research and Genetic Epidemiology Unit, School of Basic & Medical Biosciences, King’s College London
- Andrew E. Pink
- St John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London
- The Acne Genetic Study Group
- Isabelle Carlavan
- Research Department, Galderma R&D
- Johannes J. Voegel
- Research Department, Galderma R&D
- Timothy D. Spector
- Twin Research and Genetic Epidemiology Unit, School of Basic & Medical Biosciences, King’s College London
- Richard C. Trembath
- Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King’s College London
- John A. McGrath
- St John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London
- Catherine H. Smith
- St John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London
- Jonathan N. Barker
- St John’s Institute of Dermatology, School of Basic & Medical Biosciences, King’s College London
- Michael A. Simpson
- Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King’s College London
- DOI
- https://doi.org/10.1038/s41467-018-07459-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk.
