Biomechanics in ascending aortic aneurysms correlate with tissue composition and strengthCentral MessagePerspective
Miriam Nightingale, MASc,
Alexander Gregory, MD,
Taisiya Sigaeva, PhD,
Gary M. Dobson, MDCM, MSc, DIC,
Paul W.M. Fedak, MD, PhD,
Jehangir J. Appoo, MD,
Elena S. Di Martino, PhD,
Miriam Nightingale, MASc,
Alexander Gregory, MD,
Richard Beddoes, MSc,
Alicia Nickel, MD,
Samaneh Sattari, MSc,
Taisiya Sigaeva, PhD,
Amy Bromley, MD,
Jehangir J. Appoo, MD,
Elena S. Di Martino, PhD
Affiliations
Miriam Nightingale, MASc
Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Address for reprints: Miriam Nightingale, MASc, ICT 250 University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4.
Alexander Gregory, MD
Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Anesthesiology, Perioperative and Pain Medicine, University of Calgary, Calgary, Alberta, Canada
Taisiya Sigaeva, PhD
Department of Systems Design Engineering, University of Waterloo, Waterloo, Ontario, Canada
Gary M. Dobson, MDCM, MSc, DIC
Department of Anesthesiology, Perioperative and Pain Medicine, University of Calgary, Calgary, Alberta, Canada
Paul W.M. Fedak, MD, PhD
Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada
Jehangir J. Appoo, MD
Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada
Elena S. Di Martino, PhD
Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada
Objective: This study correlates low strain tangential modulus (LTM) and transition zone onset (TZo) stress, biomechanical parameters that occur within the physiological range of stress seen in vivo, with tissue strength and histopathologic changes in aneurysmal ascending aortic tissue. Method: Ascending aortic aneurysm tissue samples were collected from 41 patients undergoing elective resection. Samples were subjected to planar biaxial testing to quantify LTM and TZo. These were then correlated with strength assessed from uniaxial testing and with histopathologic quantification of pathologic derangements in elastin, collagen, and proteoglycan (PG). Results: Decreased LTM and TZo were correlated with reduced strength (P < .05), PG content (P < .05), and elastin content (P < .05). Reduced TZo also was correlated with increased elastin fragmentation (P < .05). Conclusions: LTM and TZo are correlated with common biomechanical and histopathologic alterations in ascending aortic aneurysm tissue that are thought to relate to the risk of acute aortic syndromes. LTM and TZo are measured under conditions approximating in vivo physiology and have the potential to be obtained noninvasively using medical imaging techniques. Therefore, they represent parameters that warrant future study as potential contributors to our growing knowledge of pathophysiology, disease progression, and risk stratification of aortic disease.
