Molecules (Jun 2019)
Recyclable and Stable <i>α</i>-Methylproline-Derived Chiral Ligands for the Chemical Dynamic Kinetic Resolution of free <i>C,N</i>-Unprotected <i>α</i>-Amino Acids
Abstract
A novel special designed, stable, and recyclable chiral ligand bearing a quaternary carbon was developed for chemical dynamic kinetic resolution (DKR) of free C,N-unprotected racemic α-amino acids via Schiff base intermediates. This method furnishes high yields with excellent enantioselectivity, has a broad substrate scope, and uses operationally simple and convenient conditions. The present chemical DKR is a practical and useful method for the preparation of enantiopure α-amino acids.
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