Complex Virome in a Mesenteric Lymph Node from a Californian Sea Lion (<i>Zalophus californianus)</i> with Polyserositis and Steatitis
Eda Altan,
Martha A. Delaney,
Kathleen M. Colegrove,
Terry R. Spraker,
Elizabeth A. Wheeler,
Xutao Deng,
Yanpeng Li,
Frances M. D. Gulland,
Eric Delwart
Affiliations
Eda Altan
Vitalant Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
Martha A. Delaney
Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 3300 Golf Road, Brookfield, IL 60513, USA
Kathleen M. Colegrove
Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 3300 Golf Road, Brookfield, IL 60513, USA
Terry R. Spraker
Veterinary Diagnostic Laboratory, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80526, USA
Elizabeth A. Wheeler
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Bustad 471, Pullman, WA 99164, USA
Xutao Deng
Vitalant Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
Yanpeng Li
Vitalant Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
Frances M. D. Gulland
Karen C. Drayer Wildlife Heath Center, School of Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
Eric Delwart
Vitalant Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
An emaciated subadult free-ranging California sea lion (Csl or Zalophus californianus) died following stranding with lesions similar to 11 other stranded animals characterized by chronic disseminated granulomatous inflammation with necrotizing steatitis and vasculitis, involving visceral adipose tissues in the thoracic and peritoneal cavities. Histologically, affected tissues had extensive accumulations of macrophages with perivascular lymphocytes, plasma cells, and fewer neutrophils. Using viral metagenomics on a mesenteric lymph node six mammalian viruses were identified consisting of novel parvovirus, polyomavirus, rotavirus, anellovirus, and previously described Csl adenovirus 1 and Csl bocavirus 4. The causal or contributory role of these viruses to the gross and histologic lesions of this sea lion remains to be determined.
