Nature Communications (Jul 2020)
A molecular map of murine lymph node blood vascular endothelium at single cell resolution
- Kevin Brulois,
- Anusha Rajaraman,
- Agata Szade,
- Sofia Nordling,
- Ania Bogoslowski,
- Denis Dermadi,
- Milladur Rahman,
- Helena Kiefel,
- Edward O’Hara,
- Jasper J. Koning,
- Hiroto Kawashima,
- Bin Zhou,
- Dietmar Vestweber,
- Kristy Red-Horse,
- Reina E. Mebius,
- Ralf H. Adams,
- Paul Kubes,
- Junliang Pan,
- Eugene C. Butcher
Affiliations
- Kevin Brulois
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Anusha Rajaraman
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Agata Szade
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Sofia Nordling
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Ania Bogoslowski
- Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary
- Denis Dermadi
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Milladur Rahman
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Helena Kiefel
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Edward O’Hara
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Jasper J. Koning
- Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center
- Hiroto Kawashima
- Department of Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
- Bin Zhou
- The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- Dietmar Vestweber
- Department Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine
- Kristy Red-Horse
- Department of Biology, Stanford University
- Reina E. Mebius
- Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center
- Ralf H. Adams
- Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine
- Paul Kubes
- Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary
- Junliang Pan
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- Eugene C. Butcher
- Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-17291-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
The origin and diversity of blood vascular endothelial cells (BEC) in lymphoid tissues is unclear. Here, the authors profile murine BECs from peripheral lymph nodes by single cell analysis and identify subsets of cells specialised for immune cell recruitment and vascular homeostasis.
