Nature Communications (Oct 2018)

Lipopolysaccharide-affinity copolymer senses the rapid motility of swarmer bacteria to trigger antimicrobial drug release

  • Shengtao Lu,
  • Wuguo Bi,
  • Quanchao Du,
  • Sheetal Sinha,
  • Xiangyang Wu,
  • Arnold Subrata,
  • Surajit Bhattacharjya,
  • Bengang Xing,
  • Edwin K. L. Yeow

DOI
https://doi.org/10.1038/s41467-018-06729-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Urinary tract infections are a common side effect of urethral catheters. Here, the authors report on the development of antibiotic loaded NPs with functional polymer coatings which attach too and are removed by motile bacteria to trigger the release of antibiotic.