Clinical significance of changes of chemokine MIP-1 alpha and MIP-1 beta levels in peripheral blood of patients with diabetic retinopathy

Abstract

AIM: To observe the changes of chemokine macrophage inflammatory protein(MIP-1α)and MIP-1β in peripheral blood of patients with diabetic retinopathy and to analyze its clinical significance. METHODS: The patients with diabetic retinopathy(DM group), monproli fertive diabetic retinopathy(NPDR group)and proliferative diabetic retinopathy(PDR group)were selected in Foshan Fifth People's Hospital and the Fourth People's Hospital of Nanhai District, Foshan. There were 50 patients were treated in each group, and 50 healthy persons(control group)were selected for the same period. The differences in the levels of chemokine MIP-1 alpha, MIP-1 beta, blood glucose and cytokines in peripheral blood of patients with different groups were observed. The correlation between the levels of chemokine MIP-1α and MIP-1β of peripheral blood in patients with diabetic retinopathy and the level of blood glucose and cytokines was analyzed by Pearson correlation analysis. RESULTS: The levels of MIP-1α, MIP-1β and mean blood glucose(MBG)in the DM group were higher than those in the control group(t=6.306, 2.954, 3.617; Pt=27.216, 7.778, 3.214; Pt=6.620, 3.461, 3.378; Pt=10.260, 12.611, 4.108; PCONCLUSION: The levels of MIP-1α and MIP-1β in patients with PDR are relatively high, and are positively correlated with blood glucose and cytokines levels.

Keywords

• diabetes retinopathy
• cytokines
• macrophage inflammatory protein