Nature Communications (Sep 2021)
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
- Emilie Crouchet,
- Simonetta Bandiera,
- Naoto Fujiwara,
- Shen Li,
- Hussein El Saghire,
- Mirian Fernández-Vaquero,
- Tobias Riedl,
- Xiaochen Sun,
- Hadassa Hirschfield,
- Frank Jühling,
- Shijia Zhu,
- Natascha Roehlen,
- Clara Ponsolles,
- Laura Heydmann,
- Antonio Saviano,
- Tongqi Qian,
- Anu Venkatesh,
- Joachim Lupberger,
- Eloi R. Verrier,
- Mozhdeh Sojoodi,
- Marine A. Oudot,
- François H. T. Duong,
- Ricard Masia,
- Lan Wei,
- Christine Thumann,
- Sarah C. Durand,
- Victor González-Motos,
- Danijela Heide,
- Jenny Hetzer,
- Shigeki Nakagawa,
- Atsushi Ono,
- Won-Min Song,
- Takaaki Higashi,
- Roberto Sanchez,
- Rosa S. Kim,
- C. Billie Bian,
- Karun Kiani,
- Tom Croonenborghs,
- Aravind Subramanian,
- Raymond T. Chung,
- Beate K. Straub,
- Detlef Schuppan,
- Maliki Ankavay,
- Laurence Cocquerel,
- Evelyne Schaeffer,
- Nicolas Goossens,
- Anna P. Koh,
- Milind Mahajan,
- Venugopalan D. Nair,
- Ganesh Gunasekaran,
- Myron E. Schwartz,
- Nabeel Bardeesy,
- Alex K. Shalek,
- Orit Rozenblatt-Rosen,
- Aviv Regev,
- Emanuele Felli,
- Patrick Pessaux,
- Kenneth K. Tanabe,
- Mathias Heikenwälder,
- Catherine Schuster,
- Nathalie Pochet,
- Mirjam B. Zeisel,
- Bryan C. Fuchs,
- Yujin Hoshida,
- Thomas F. Baumert
Affiliations
- Emilie Crouchet
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Simonetta Bandiera
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Naoto Fujiwara
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Shen Li
- Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School
- Hussein El Saghire
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Mirian Fernández-Vaquero
- Division of Chronic Inflammation and Cancer, German Cancer Research Center
- Tobias Riedl
- Division of Chronic Inflammation and Cancer, German Cancer Research Center
- Xiaochen Sun
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Hadassa Hirschfield
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Frank Jühling
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Shijia Zhu
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Natascha Roehlen
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Clara Ponsolles
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Laura Heydmann
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Antonio Saviano
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Tongqi Qian
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Anu Venkatesh
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Joachim Lupberger
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Eloi R. Verrier
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Mozhdeh Sojoodi
- Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School
- Marine A. Oudot
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- François H. T. Duong
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Ricard Masia
- Department of Pathology, Massachusetts General Hospital
- Lan Wei
- Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School
- Christine Thumann
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Sarah C. Durand
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Victor González-Motos
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Danijela Heide
- Division of Chronic Inflammation and Cancer, German Cancer Research Center
- Jenny Hetzer
- Division of Chronic Inflammation and Cancer, German Cancer Research Center
- Shigeki Nakagawa
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Atsushi Ono
- Department of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima University
- Won-Min Song
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Takaaki Higashi
- Department of Gastroenterological Surgery, Kumamoto University
- Roberto Sanchez
- Department of Pharmacological Sciences and Drug Discovery Institute, Icahn School of Medicine at Mount Sinai
- Rosa S. Kim
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- C. Billie Bian
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Karun Kiani
- Department of Neurology, Harvard Medical School
- Tom Croonenborghs
- Department of Neurology, Harvard Medical School
- Aravind Subramanian
- Department of Neurology, Harvard Medical School
- Raymond T. Chung
- Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School
- Beate K. Straub
- Institute of Pathology, University Medicine, Johannes Gutenberg University
- Detlef Schuppan
- Institute for Translational Immunology and Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center
- Maliki Ankavay
- University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 8204-CIIL- Center for Infection and Immunity of Lille
- Laurence Cocquerel
- University of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 8204-CIIL- Center for Infection and Immunity of Lille
- Evelyne Schaeffer
- CNRS UPR3572 Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moléculaire et Cellulaire (IBMC)
- Nicolas Goossens
- Division of Gastroenterology and Hepatology, Geneva University Hospital
- Anna P. Koh
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Milind Mahajan
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Venugopalan D. Nair
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Ganesh Gunasekaran
- Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai
- Myron E. Schwartz
- Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai
- Nabeel Bardeesy
- Massachusetts General Hospital Cancer Center; Harvard Medical School, Cambridge St. CPZN 4216
- Alex K. Shalek
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Orit Rozenblatt-Rosen
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Aviv Regev
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Emanuele Felli
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Patrick Pessaux
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Kenneth K. Tanabe
- Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School
- Mathias Heikenwälder
- Division of Chronic Inflammation and Cancer, German Cancer Research Center
- Catherine Schuster
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Nathalie Pochet
- Department of Neurology, Harvard Medical School
- Mirjam B. Zeisel
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- Bryan C. Fuchs
- Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School
- Yujin Hoshida
- Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center
- Thomas F. Baumert
- Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- DOI
- https://doi.org/10.1038/s41467-021-25468-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.
