Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression

Sakshi Goel; Vipul Bhatia; Sushmita Kundu; Tanay Biswas; Shannon Carskadon; Nilesh Gupta; Mohammad Asim; Colm Morrissey; Nallasivam Palanisamy; Bushra Ateeq

doi:10.1038/s41467-021-25623-2

Nature Communications (Sep 2021)

Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression

Sakshi Goel,
Vipul Bhatia,
Sushmita Kundu,
Tanay Biswas,
Shannon Carskadon,
Nilesh Gupta,
Mohammad Asim,
Colm Morrissey,
Nallasivam Palanisamy,
Bushra Ateeq

Affiliations

Sakshi Goel: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur
Vipul Bhatia: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur
Sushmita Kundu: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur
Tanay Biswas: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur
Shannon Carskadon: Vattikuti Urology Institute, Department of Urology, Henry Ford Health System
Nilesh Gupta: Department of Pathology, Henry Ford Health System
Mohammad Asim: Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey
Colm Morrissey: Department of Urology, University of Washington
Nallasivam Palanisamy: Vattikuti Urology Institute, Department of Urology, Henry Ford Health System
Bushra Ateeq: Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur

DOI: https://doi.org/10.1038/s41467-021-25623-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 22

Abstract

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Distal-less homeobox 1 (DLX1) is reported as a prostate cancer (PCa) diagnostic biomarker, but the mechanism for its upregulation in PCa is unclear. Here the authors show that ERG, AR and FOXA1 transcriptionally regulates DLX1 expression in PCa, and the inhibition of this ERG/AR transcriptional circuitry with a BET inhibitor reduces the oncogenic effects of DLX1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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