Nature Communications (Jan 2018)
Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes
- Letizia Mariotti,
- Gabriele Losi,
- Annamaria Lia,
- Marcello Melone,
- Angela Chiavegato,
- Marta Gómez-Gonzalo,
- Michele Sessolo,
- Serena Bovetti,
- Angelo Forli,
- Micaela Zonta,
- Linda Maria Requie,
- Iacopo Marcon,
- Arianna Pugliese,
- Cécile Viollet,
- Bernhard Bettler,
- Tommaso Fellin,
- Fiorenzo Conti,
- Giorgio Carmignoto
Affiliations
- Letizia Mariotti
- Neuroscience Institute, National Research Council (CNR)
- Gabriele Losi
- Neuroscience Institute, National Research Council (CNR)
- Annamaria Lia
- Neuroscience Institute, National Research Council (CNR)
- Marcello Melone
- Department of Experimental and Clinical Medicine, Università Politecnica delle Marche
- Angela Chiavegato
- Department of Biomedical Sciences, Università degli Studi di Padova
- Marta Gómez-Gonzalo
- Neuroscience Institute, National Research Council (CNR)
- Michele Sessolo
- Neuroscience Institute, National Research Council (CNR)
- Serena Bovetti
- Optical Approches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
- Angelo Forli
- Optical Approches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
- Micaela Zonta
- Neuroscience Institute, National Research Council (CNR)
- Linda Maria Requie
- Neuroscience Institute, National Research Council (CNR)
- Iacopo Marcon
- Neuroscience Institute, National Research Council (CNR)
- Arianna Pugliese
- Department of Experimental and Clinical Medicine, Università Politecnica delle Marche
- Cécile Viollet
- Inserm UMR894, Center for Psychiatry and Neuroscience, Université Paris-Descartes
- Bernhard Bettler
- Departement of Biomedicine, University of Basel
- Tommaso Fellin
- Optical Approches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
- Fiorenzo Conti
- Department of Experimental and Clinical Medicine, Università Politecnica delle Marche
- Giorgio Carmignoto
- Neuroscience Institute, National Research Council (CNR)
- DOI
- https://doi.org/10.1038/s41467-017-02642-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Interneurons in the neocortex have functional and morphological subtypes. Here, Mariotti and colleagues show that activation of parvalbumin-expressing interneurons evokes depressing calcium responses in astrocytes while somatostatin-expressing interneurons evoke potentiating astrocytic responses.
