International Journal of Molecular Sciences (Jun 2019)

Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases

  • Fabiane Valentini Francisqueti-Ferron,
  • Artur Junio Togneri Ferron,
  • Jéssica Leite Garcia,
  • Carol Cristina Vágula de Almeida Silva,
  • Mariane Róvero Costa,
  • Cristina Schmitt Gregolin,
  • Fernando Moreto,
  • Ana Lúcia A. Ferreira,
  • Igor Otávio Minatel,
  • Camila Renata Correa

DOI
https://doi.org/10.3390/ijms20133208
Journal volume & issue
Vol. 20, no. 13
p. 3208

Abstract

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The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders.

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