Biodegradable copper vanadate-based hydrogel with photocatalytic/photothermal therapy for infected diabetic wound healing

Lili Sheng; Yanping Feng; Shuting Wu; Chen Wang; Ruiyang Sun; Qishu Jin; Dongmin Chen; Zhaowenbin Zhang; He Xu; Zhihong Dong; Hong Zhu; Chen Yang; Jiang Chang

Materials & Design (Oct 2024)

Biodegradable copper vanadate-based hydrogel with photocatalytic/photothermal therapy for infected diabetic wound healing

Lili Sheng,
Yanping Feng,
Shuting Wu,
Chen Wang,
Ruiyang Sun,
Qishu Jin,
Dongmin Chen,
Zhaowenbin Zhang,
He Xu,
Zhihong Dong,
Hong Zhu,
Chen Yang,
Jiang Chang

Affiliations

Lili Sheng: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Bloomage Biotechnology Co., Ltd., Jinan, Shandong 250101, China
Yanping Feng: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; College of Mechanical Engineering, Chengdu University, Chengdu, Sichuan 610106, China
Shuting Wu: National Key Clinical Specialty (Wound Healing), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Wenzhou 325000, China
Chen Wang: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China
Ruiyang Sun: National Key Clinical Specialty (Wound Healing), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Wenzhou 325000, China
Qishu Jin: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China
Dongmin Chen: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China
Zhaowenbin Zhang: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
He Xu: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai 200234, China; Corresponding authors at: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Zhihong Dong: College of Mechanical Engineering, Chengdu University, Chengdu, Sichuan 610106, China; Corresponding authors at: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Hong Zhu: National Key Clinical Specialty (Wound Healing), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Wenzhou 325000, China; Corresponding authors at: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Chen Yang: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; National Key Clinical Specialty (Wound Healing), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Corresponding authors at: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Jiang Chang: Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

Journal volume & issue: Vol. 246
p. 113358

Abstract

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In light of the clinical challenges posed by bacterial infection and vascular damage in chronic diabetic wounds, this study presents a novel bioactive copper vanadate-based hydrogel (CVH) with multiple functions including the sustained release of copper and vanadium ions, photocatalytic activity under visible (VIS) light, and photothermal ability under near-infrared (NIR) light. In vitro experiments demonstrated that CVH effectively repairs high glucose-impaired human umbilical vein endothelial cells (HUVECs) and exhibits potent antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, the dual biological functions are augmented by the NIR-light-induced mild photothermal effect, demonstrating a synergistic effect. The infected diabetic wound model further substantiates the therapeutic efficacy of the CVH dressing in eliminating bacteria and promoting angiogenesis under VIS/NIR light irradiation. Collectively, the CVH dressing demonstrates significant potential as a therapeutic intervention for managing chronic diabetic wounds.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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