Frontiers in Molecular Biosciences (Apr 2022)

Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects

  • Veronica Ghini,
  • Veronica Ghini,
  • Veronica Ghini,
  • Laura Maggi,
  • Alessio Mazzoni,
  • Michele Spinicci,
  • Michele Spinicci,
  • Lorenzo Zammarchi,
  • Lorenzo Zammarchi,
  • Alessandro Bartoloni,
  • Alessandro Bartoloni,
  • Francesco Annunziato,
  • Francesco Annunziato,
  • Paola Turano,
  • Paola Turano,
  • Paola Turano

DOI
https://doi.org/10.3389/fmolb.2022.839809
Journal volume & issue
Vol. 9

Abstract

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1H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition.

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