Malignant cerebral infarction after ChAdOx1 nCov-19 vaccination: a catastrophic variant of vaccine-induced immune thrombotic thrombocytopenia

M. De Michele; M. Iacobucci; A. Chistolini; E. Nicolini; F. Pulcinelli; B. Cerbelli; E. Merenda; O. G. Schiavo; E. Sbardella; I. Berto; L. Petraglia; N. Caracciolo; M. Chiara; S. Truglia; D. Toni

doi:10.1038/s41467-021-25010-x

Nature Communications (Aug 2021)

Malignant cerebral infarction after ChAdOx1 nCov-19 vaccination: a catastrophic variant of vaccine-induced immune thrombotic thrombocytopenia

M. De Michele,
M. Iacobucci,
A. Chistolini,
E. Nicolini,
F. Pulcinelli,
B. Cerbelli,
E. Merenda,
O. G. Schiavo,
E. Sbardella,
I. Berto,
L. Petraglia,
N. Caracciolo,
M. Chiara,
S. Truglia,
D. Toni

Affiliations

M. De Michele: Emergency Department, Stroke Unit, Sapienza University of Rome
M. Iacobucci: Neuroradiology Unit, Department of Human Neurosciences, Sapienza University of Rome
A. Chistolini: Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome
E. Nicolini: Emergency Department, Stroke Unit, Sapienza University of Rome
F. Pulcinelli: Department of Experimental Medicine, Sapienza University of Rome
B. Cerbelli: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome
E. Merenda: Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome
O. G. Schiavo: Emergency Department, Stroke Unit, Sapienza University of Rome
E. Sbardella: Emergency Department, Stroke Unit, Sapienza University of Rome
I. Berto: Department of Human Neurosciences, Sapienza University of Rome
L. Petraglia: Emergency Department, Stroke Unit, Sapienza University of Rome
N. Caracciolo: Department of Human Neurosciences, Sapienza University of Rome
M. Chiara: Neurosurgery, Department of Human Neurosciences, Sapienza University of Rome
S. Truglia: Lupus Clinic, Rheumatology Unit, Dipartimento Di Scienze Cliniche Internistiche Anestesiologiche e Cardiovascolari, Sapienza University of Rome
D. Toni: Department of Human Neurosciences, Sapienza University of Rome

DOI: https://doi.org/10.1038/s41467-021-25010-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 7

Abstract

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Vaccination is an effective strategy in suppressing COVID-19 pandemic, but rare adverse effects have been reported, including cerebral venous thrombosis. Here the authors report two cases of middle cerebral artery infarct within 9-10 days following ChAdOx1 nCov-19 vaccination that also manifest pulmonary and portal vein thrombosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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