ACUTE PANCREATITIS, DIAGNOSTICS AND PROGNOSIS

Abstract

Purpose: to study the levels of lactoferrin (LF) and macroglobulin (MG) in the serum of patients with acute pancreatitis depending on the severity of inflammation and prediction of disease outcome.Materials and methods: 93 patients were observed with various forms of acute pancreatitis in the serum of them in the dynamics by radial immunodiffusion method there were investigated the concentration of MG and ELISA - the level of LF.Results: there was an increase in the level of WBF patients depending on various forms of acute pancreatitis and severity of inflammation and clear tendency to decrease with increasing level of MG severity in pancreatitis DIF sequence, SP, IP.Summary: In patients with acute pancreatitis there was a high concentration and low level of LF - MG which may indicate serious destructive processes in the pancreas. Following the treatment the level of LF decreases and MG - rises to normal which is an important diagnostic criterion for assessing the severity of the inflammatory process and the effectiveness of treatment for this disease. Considering these, indexes of LF and MG can be included into the standard of diagnostics and monitoring of treatment in various forms of acute pancreatitis.

Keywords

• acute pancreatitis
• α2-macroglobulin (mg)
• lactoferrin (lf)