Frontiers in Psychiatry (Feb 2023)

Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients

  • Kevin Swierkosz-Lenart,
  • Joao Flores Alves Dos Santos,
  • Julien Elowe,
  • Julien Elowe,
  • Anne-Hélène Clair,
  • Julien F. Bally,
  • Françoise Riquier,
  • Jocelyne Bloch,
  • Bogdan Draganski,
  • Bogdan Draganski,
  • Marie-Thérèse Clerc,
  • Beatriz Pozuelo Moyano,
  • Armin von Gunten,
  • Luc Mallet,
  • Luc Mallet,
  • Luc Mallet

DOI
https://doi.org/10.3389/fpsyt.2023.1065812
Journal volume & issue
Vol. 14

Abstract

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Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30–40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving. The aim of this paper is to provide a summary of the current knowledge about OCD treatment, while also discussing the more recent proposals for defining resistance.

Keywords