Nature Communications (Sep 2017)

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

  • Rhianna C. Laker,
  • Joshua C. Drake,
  • Rebecca J. Wilson,
  • Vitor A. Lira,
  • Bevan M. Lewellen,
  • Karen A. Ryall,
  • Carleigh C. Fisher,
  • Mei Zhang,
  • Jeffrey J. Saucerman,
  • Laurie J. Goodyear,
  • Mondira Kundu,
  • Zhen Yan

DOI
https://doi.org/10.1038/s41467-017-00520-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Exercise is associated with biogenesis and removal of dysfunctional mitochondria. Here the authors use a mitochondrial reporter gene to demonstrate the occurrence of mitophagy following exercise in mice, and show this is dependent on AMPK and ULK1 signaling.