PLoS ONE (Jan 2021)

Prognostic value of postoperative decrease in serum albumin on surgically resected early-stage non-small cell lung carcinoma: A multicenter retrospective study.

  • Fumihiko Kinoshita,
  • Tetsuzo Tagawa,
  • Takanori Yamashita,
  • Tomoyoshi Takenaka,
  • Taichi Matsubara,
  • Gouji Toyokawa,
  • Kazuki Takada,
  • Taro Oba,
  • Atsushi Osoegawa,
  • Koji Yamazaki,
  • Mitsuhiro Takenoyama,
  • Mototsugu Shimokawa,
  • Naoki Nakashima,
  • Masaki Mori

DOI
https://doi.org/10.1371/journal.pone.0256894
Journal volume & issue
Vol. 16, no. 9
p. e0256894

Abstract

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BackgroundPreoperative nutritional status is an important host-related prognostic factor for non-small cell lung carcinoma (NSCLC); however, the significance of postoperative changes in nutritional status remains unclear. This study aimed to elucidate the significance of postoperative decreases in serum albumin (ΔAlb) on the outcomes of early-stage NSCLC.MethodsWe analyzed 443 training cohort (TC) and 642 validation cohort (VC) patients with pStage IA NSCLC who underwent surgery and did not recur within 1 year. We measured preoperative serum albumin levels (preAlb) and postoperative levels 1 year after surgery (postAlb), and calculated ΔAlb as (preAlb - postAlb)/preAlb × 100%. A cutoff value of 11% for ΔAlb was defined on the basis of the receiver operating characteristic curve for the TC.ResultsPatients were divided into ΔAlb-Decreased and ΔAlb-Stable groups, including 100 (22.6%) and 343 (77.4%) in the TC, and 58 (9.0%) and 584 (90.1%) in the VC. ΔAlb-Decreased was associated with male sex (p = 0.0490), smoking (p = 0.0156), and non-adenocarcinoma (pConclusionWe demonstrated a negative impact of postoperative decrease of the serum albumin on the prognosis of patients with early-stage NSCLC. Postoperative changes in nutritional status might be important in NSCLC outcomes.