Nature Communications (Sep 2017)
TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine
- C. C. Bain,
- J. Montgomery,
- C. L. Scott,
- J. M. Kel,
- M. J. H. Girard-Madoux,
- L. Martens,
- T. F. P. Zangerle-Murray,
- J. Ober-Blöbaum,
- D. Lindenbergh-Kortleve,
- J. N. Samsom,
- S. Henri,
- T. Lawrence,
- Y. Saeys,
- B. Malissen,
- M. Dalod,
- B. E. Clausen,
- A. McI. Mowat
Affiliations
- C. C. Bain
- Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow
- J. Montgomery
- Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow
- C. L. Scott
- Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow
- J. M. Kel
- Department of Immunology, Erasmus MC, University Medical Center
- M. J. H. Girard-Madoux
- Department of Immunology, Erasmus MC, University Medical Center
- L. Martens
- Department of Biomedical Molecular Biology, Ghent University
- T. F. P. Zangerle-Murray
- Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow
- J. Ober-Blöbaum
- Department of Immunology, Erasmus MC, University Medical Center
- D. Lindenbergh-Kortleve
- Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus Medical Center
- J. N. Samsom
- Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus Medical Center
- S. Henri
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2, INSERM, U1104, CNRS UMR7280
- T. Lawrence
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2, INSERM, U1104, CNRS UMR7280
- Y. Saeys
- Data Mining and Modeling for Biomedicine, VIB Inflammation Research Center
- B. Malissen
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2, INSERM, U1104, CNRS UMR7280
- M. Dalod
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2, INSERM, U1104, CNRS UMR7280
- B. E. Clausen
- Department of Immunology, Erasmus MC, University Medical Center
- A. McI. Mowat
- Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow
- DOI
- https://doi.org/10.1038/s41467-017-00658-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103−CD11b+ cells and that they contribute to the generation of Th17 and regulatory T cells
