Nature Communications (Jan 2021)

Perspectives on skeletal muscle stem cells

  • F. Relaix,
  • M. Bencze,
  • M. J. Borok,
  • A. Der Vartanian,
  • F. Gattazzo,
  • D. Mademtzoglou,
  • S. Perez-Diaz,
  • A. Prola,
  • P. C. Reyes-Fernandez,
  • A. Rotini,
  • Taglietti

DOI
https://doi.org/10.1038/s41467-020-20760-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Skeletal muscle has a remarkable regenerative capacity, which can largely be attributed to resident muscle stem cells (MuSCs). Here, the authors review the molecular mechanisms regulating MuSC quiescence, activation and proliferation, how these processes are regulated by the stem cell niche, and the role of MuSCs in neuromuscular diseases.