Association study of the Ubiquilin gene with Alzheimer's disease

Faiza Bensemain; Julien Chapuis; Jinzhou Tian; Jing Shi; Uma Thaker; Corinne Lendon; Takeshi Iwatsubo; Philippe Amouyel; David Mann; Jean-Charles Lambert

Neurobiology of Disease (Jun 2006)

Association study of the Ubiquilin gene with Alzheimer's disease

Faiza Bensemain,
Julien Chapuis,
Jinzhou Tian,
Jing Shi,
Uma Thaker,
Corinne Lendon,
Takeshi Iwatsubo,
Philippe Amouyel,
David Mann,
Jean-Charles Lambert

Affiliations

Faiza Bensemain: INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, BP 245, 5019 Lille Cédex, France
Julien Chapuis: INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, BP 245, 5019 Lille Cédex, France
Jinzhou Tian: Department of Care of the Elderly, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Stott Lane, Salford M6 8HD, UK
Jing Shi: Department of Care of the Elderly, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Stott Lane, Salford M6 8HD, UK
Uma Thaker: Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Stott Lane, Salford M6 8HD, UK
Corinne Lendon: Department of Molecular Psychiatry, Division of Neuroscience, Queen Elizabeth Psychiatry Hospital, University of Birmingham, Birmingham B15 2QZ, UK
Takeshi Iwatsubo: Department of Neuropathology and Neuroscience, University of Tokyo, Tokyo 113, Japan
Philippe Amouyel: INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, BP 245, 5019 Lille Cédex, France
David Mann: Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Stott Lane, Salford M6 8HD, UK
Jean-Charles Lambert: INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, BP 245, 5019 Lille Cédex, France; Corresponding author. Fax: +33 3 20 87 78 94.

Journal volume & issue: Vol. 22, no. 3
pp. 691 – 693

Abstract

Read online

Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case–control population. Furthermore, no relationship between this polymorphism and Aβ load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

About the journal

Abstract

Keywords