The quality of life in children with spinal muscular atrophy: a case–control study

Gholamreza Zamani; Mahmoud Reza Ashrafi; Homa Ghabeli; Masood Ghahvechi Akbari; Mahmoud Mohammadi; Reza Shervin Badv; Sareh Hosseinpour; Roya Haghighi; Elham Pourbakhtyaran; Nahid Khosroshahi; Morteza Heidari

doi:10.1186/s12887-022-03751-y

BMC Pediatrics (Dec 2022)

The quality of life in children with spinal muscular atrophy: a case–control study

Gholamreza Zamani,
Mahmoud Reza Ashrafi,
Homa Ghabeli,
Masood Ghahvechi Akbari,
Mahmoud Mohammadi,
Reza Shervin Badv,
Sareh Hosseinpour,
Roya Haghighi,
Elham Pourbakhtyaran,
Nahid Khosroshahi,
Morteza Heidari

Affiliations

Gholamreza Zamani: Pediatrics Center of Excellence, Department of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences
Mahmoud Reza Ashrafi: Pediatrics Center of Excellence, Department of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences
Homa Ghabeli: Pediatrics Center of Excellence, Department of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences
Masood Ghahvechi Akbari: Department of Physical Medicine and Rehabilitation, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
Mahmoud Mohammadi: Pediatrics Center of Excellence, Department of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences
Reza Shervin Badv: Pediatrics Center of Excellence, Department of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences
Sareh Hosseinpour: Department of Pediatric Neurology, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences
Roya Haghighi: Pediatrics Center of Excellence, Department of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences
Elham Pourbakhtyaran: Pediatrics Center of Excellence, Department of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences
Nahid Khosroshahi: Department of Pediatric Neurology, Bahrami Children’s Hospital, Tehran University of Medical Sciences
Morteza Heidari: Pediatrics Center of Excellence, Department of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences

DOI: https://doi.org/10.1186/s12887-022-03751-y
Journal volume & issue: Vol. 22, no. 1
pp. 1 – 5

Abstract

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Abstract Objectives This study aimed to analyze the health-related quality of life (HRQoL) of patients with spinal muscular atrophy (SMA) based on the type of SMA, demographic and clinical features and compare HRQoL of these patients with a matched healthy control group. Methods This was a case–control study of Patients with SMA in Iran. Sixty-six patients with SMA type II and III aged 8–18 years and also 264 healthy age, sex, and socio-economic matched individuals were enrolled. To assess the quality of life, we used the Persian version of the KIDSCREEN-27. Results The health-related quality of life between children with type II and type III SMA was not significant in all 5 subscales. However, HRQoL in healthy children was significantly higher than in SMA children in all 5 subscales. Conclusion The quality of life in children with SMA was lower than the healthy control group in all subscales, and physical well-being and psychosocial aspects are the main domains of life impaired by SMA disease. However, no significant difference between the quality of life in children with SMA type II and type III was observed.

Published in BMC Pediatrics

ISSN: 1471-2431 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Pediatrics
Website: https://bmcpediatr.biomedcentral.com

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Abstract

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