Vaccine-induced Immunity Circumvented by Typical Mycobacterium tuberculosis Beijing Strains

Abstract

The frequency of typical and atypical Beijing strains of Mycobacterium tuberculosis was determined in the Netherlands; Vietnam; and Hong Kong Special Administrative Region, People’s Republic of China. The strains’ associations with drug resistance, M. bovis BCG vaccination, and patient characteristics were assessed. BCG vaccination may have positively selected the prevalent typical Beijing strains.

Keywords

• Mycobacterium tuberculosis
• Beijing strain
• vaccine escape and drug resistance
• W strain
• BCG vaccination
• drug resistance