Nature Communications (Apr 2022)
ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage
- Jun Liu,
- Xiaoying Wang,
- Ann T. Chen,
- Xingchun Gao,
- Benjamin T. Himes,
- Hongyi Zhang,
- Zeming Chen,
- Jianhui Wang,
- Wendy C. Sheu,
- Gang Deng,
- Yang Xiao,
- Pan Zou,
- Shenqi Zhang,
- Fuyao Liu,
- Yong Zhu,
- Rong Fan,
- Toral R. Patel,
- W. Mark Saltzman,
- Jiangbing Zhou
Affiliations
- Jun Liu
- Department of Neurosurgery, Yale University
- Xiaoying Wang
- Department of Neurosurgery, Yale University
- Ann T. Chen
- Department of Neurosurgery, Yale University
- Xingchun Gao
- Department of Neurosurgery, Yale University
- Benjamin T. Himes
- Department of Biomedical Engineering, Yale University
- Hongyi Zhang
- Department of Neurosurgery, Yale University
- Zeming Chen
- Department of Neurosurgery, Yale University
- Jianhui Wang
- Department of Pathology, Yale University
- Wendy C. Sheu
- Department of Neurosurgery, Yale University
- Gang Deng
- Department of Neurosurgery, Yale University
- Yang Xiao
- Department of Biomedical Engineering, Yale University
- Pan Zou
- Department of Neurosurgery, Yale University
- Shenqi Zhang
- Department of Neurosurgery, Yale University
- Fuyao Liu
- Department of Neurosurgery, Yale University
- Yong Zhu
- School of Public Health, Yale University
- Rong Fan
- Department of Biomedical Engineering, Yale University
- Toral R. Patel
- Department of Neurosurgery, Yale University
- W. Mark Saltzman
- Department of Biomedical Engineering, Yale University
- Jiangbing Zhou
- Department of Neurosurgery, Yale University
- DOI
- https://doi.org/10.1038/s41467-022-29884-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Improved treatment of glioblastoma (GBM) can be achieved by inducing differentiation of glioblastoma stem cells (GSCs). Here, the authors show that zinc finger protein 117 (ZNF117) is a regulator of GSC differentiation via Notch signaling through interaction with JAG2, and can be targeted for therapy.
