Mesenchymal stem cells biological properties and possibilities of clinical use

Abstract

Autologic and allogeneic mesenchymal stem cells (MSC) transplantation currently is used in clinical practice for hematopoietic progenitor engraftment acceleration and graft versus host disease prophylactic and treatment. In this literature review data concerning efficacy, safety and technologies of MSC clinical use are analyzed. Biological properties of MSC received in long-term culture and mechanisms of their interaction with other cells are discussed.

Keywords

• mesenchymal stem cells (msc)
• hematopoietic stem cells transplantation
• msc transplantation
• graft versus host disease
• long-term culture