Olfactory dysfunction and modification in microbiota as early non-motor manifestations of Parkinson’s disease

Abstract

The purpose of this paper is to study the most common non-motor symptoms of the Parkinson’s disease (PD): olfactory dysfunction, constipation and associated with them variety of fecal microorganisms in patients with Parkinson’s disease.Materials and methods. We studied olfactory function in 51 patients with PD using Sniffin Sticks Test and taxonomic composition of fecal microbiota.Results. Olfactory dysfunctions (hyposmia, anosmia) were found in most patients that participated in study as well as differences in alpha-variety of gut microbiota among groups with different olfactory characteristics.Conclusion. Our findings suggest that the composition of gut microbiota must be associated with etiology and pathogenesis of PD.

Keywords

• болезнь паркинсона
• немоторные симптомы
• обоняние
• микробиота