CD115− monocytic myeloid-derived suppressor cells are precursors of OLFM4high polymorphonuclear myeloid-derived suppressor cells

Yunyun Zou; Nobuhiko Kamada; Seung-Yong Seong; Sang-Uk Seo

doi:10.1038/s42003-023-04650-3

Communications Biology (Mar 2023)

CD115− monocytic myeloid-derived suppressor cells are precursors of OLFM4high polymorphonuclear myeloid-derived suppressor cells

Yunyun Zou,
Nobuhiko Kamada,
Seung-Yong Seong,
Sang-Uk Seo

Affiliations

Yunyun Zou: Department of Biomedical Sciences, Seoul National University College of Medicine
Nobuhiko Kamada: Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan
Seung-Yong Seong: Department of Biomedical Sciences, Seoul National University College of Medicine
Sang-Uk Seo: Department of Microbiology, College of Medicine, The Catholic University of Korea

DOI: https://doi.org/10.1038/s42003-023-04650-3
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

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CD115− monocytic MDSCs, functionally distinct from CD115+ monocytic MDSCs, increase in the blood and bone marrow as tumor progresses and can give rise to OLFM4hi polymorphonuclear MDSCs outside the tumor mass.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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